Ragweed pollen as an oral vaccine delivery system: Mechanistic insights

An Heterophile Factor in Ragweed Pollen

1. There is serological evidence that ragweed pollen antigen contains a factor which causes an increased hemolysin titre for sheep cells, when injected into rabbits. 2. It remains questionable whether the antigen absorbs normal rabbit hemolysins. It does, however, absorb anti-ragweed hemolysins, as demonstrated by hemolysis inhibition test. 3. Dilution and lyophilization (Mudd-Flosdorf method) ...

Microcontainers as an oral drug delivery system

Mechanistic insights into influenza vaccine-associated narcolepsy

We previously reported an increased frequency of antibodies to hypocretin (HCRT) receptor 2 in sera obtained from narcoleptic patients who received the European AS03-adjuvanted vaccine Pandemrix (GlaxoSmithKline Biologicals, s.a.) for the global influenza A H1N1 pandemic in 2009 [A(H1N1)pdm09]. These antibodies cross-reacted with a particular fragment of influenza nucleoprotein (NP) - one of th...

Microneedle/nanoencapsulation-mediated transdermal delivery: Mechanistic insights

A systematic study was undertaken to gain more insight into the mechanism of transdermal delivery of nanoencapsulated model dyes across microneedle (MN)-treated skin, a complex process not yet explored. Rhodamine B (Rh B) and fluorescein isothiocyanate (FITC) as model hydrophilic and hydrophobic small/medium-size molecules, respectively, were encapsulated in poly lactic-co-glycolic acid (PLGA) ...

Characterizing and controlling the loading of Vipera albicornuta venom in chitosan nanoparticles as an adjuvant and vaccine delivery system

The aim of this study was designing and preparing the chitosan nanoparticles (CS-NPs) loading with snake (Vipera albicornuta) venom as well as evaluating the influence of different factors on the encapsulation efficiency (EE) and loading capacity (LC) of venom. The morphologies and characteristics of CS-NPs were determined by scanning electron microscopy (SEM), Fourier transform infrared spectr...